California News Times

Two scientists received the Nobel Prize in Medicine on Monday. It was a discovery of how the human body perceives temperature and touch, which could lead to new ways to treat pain and heart disease. Americans David Julius and Aldem Patapoutian have separately identified receptors on the skin that respond to heat and pressure, and researchers are working on drugs that target them. Some hope the results will ultimately lead to pain management that reduces reliance on highly addictive opioids. But the breakthroughs that occurred decades ago have yet to produce many effective new therapies. Julius of the University of California, San Francisco, used capsaicin, the active ingredient in chili peppers, to identify heat-responsive neural sensors. That’s what the Nobel Committee said. Patapoutian of the Scripps Research Institute in La Jolla, California, discovered an intracellular pressure-sensitive sensor that responds to mechanical stimuli. “This really unlocks one of nature’s secrets,” said Commission Secretary General Thomas Pearlman when the winner was announced. “It’s a very important and profound discovery because it’s really important to our survival.” The commission said its discovery was “one of the great mysteries humanity faces,” that is, us. He said that it can be achieved by how one feels the environment. The selection of winners emphasized what scientists knew about the issue before it was discovered and how much they still have to learn. “I could understand the physiology of the senses, but not how I felt the difference in temperature and pressure,” said Marin, director of the MRC Neurodevelopmental Disorders Center at King’s College London. “It is fundamental to know how our body perceives these changes, because if we know these molecules, we can use them in a targeted manner. It’s like finding a lock. And now I know the exact key needed to unlock it. “Marin may appear first when it comes to pain, but scientists take pressure off blood vessels and other organs. Understanding how and how the body senses changes in pressure can ultimately lead to drugs for heart disease. University of Michigan Research Center Richard Harris on Chronic Pain and Fatigue also said the new winners’ work could help develop new pain relievers, but said the field had long since stalled. .. The body is not always enough to deal with it. Still, the work of Julius and Patapoutian doctors will likely help better manage pain caused by extreme temperatures and chemical burns, he said. Many patients with chronic pain have not yet been seen. “Even so, Fiona Boysonade, a pain specialist at the University of Sheffield, said the Nobel Prize winner’s study was particularly relevant to one in five people worldwide who suffer from chronic pain. Pains like arthritis, migraines and chronic back pain are “major medical problems and completely inadequately treated,” she said. “Your studies can lead to the identification of new compounds that will be effective in treating pain without the disastrous effects of opioids.” This is a longstanding difficulty warning Nobel Prize winners. It is believed to have caused an addiction crisis in the United States. Julius said he woke up to what he thought was a prank phone call shortly before the awards show. “Number,” he said from his home in San Francisco. It was midnight there. It was only when his wife heard Pearlman’s voice and realized it was not a joke that he confirmed that he was the secretary-general of the commission. Julius said his wife worked with Pearlman many years ago. Julius, 65, later stated that he hoped his work would lead to the development of new pain relievers, explaining that the biology behind everyday activities could be very important. Bottom. How it works. “The Nobel Committee tweeted a photo of Patapoutian sleeping in bed while his son viewed the announcement on his computer. Born in Lebanon, Patapoutian tweeted. The prestigious award includes a gold medal and SEK 10 million (over $ 1.14 million). The award is a legacy of the Swedish inventor Alfred Nobel, who died in 1895 and who created the award. This is the first time that this prize is awarded. Further awards are given for outstanding achievements in the fields of physics, chemistry, literature, peace and economics. ___ Chen was reported from London. Associated Press author Frank Jordan contributed from Berlin.

Two scientists received the Nobel Prize in Medicine on Monday. The discovery of how the human body perceives temperature and touch has led to discoveries that could lead to new ways to treat pain and heart disease.

Americans David Julius and Aldem Patapoutian have identified separate skin receptors that respond to heat and pressure, and researchers are working on drugs to target them. Some hope the results will ultimately lead to pain management that reduces reliance on highly addictive opioids. But the breakthroughs that occurred decades ago have yet to produce many effective new therapies.

According to the Nobel Committee, Julius of the University of California, San Francisco, used capsaicin, the active ingredient in chili peppers, to identify heat-responsive neural sensors. Patapoutian of the Scripps Research Institute in La Jolla, California, discovered an intracellular pressure-sensitive sensor that responds to mechanical stimuli.

“This really unlocks one of nature’s secrets,” said Commission Secretary General Thomas Pearlman when the winner was announced. “It’s a very important and profound discovery because it’s really important to our survival.”

The commission said its discovery was “one of the great mysteries humanity faces,” that is, how we think about the environment.

Oscar Marine, director of the MRC Neurodevelopmental Disorders Center at King’s College London, emphasized that the winner’s choice was that few scientists knew about the issue before it was discovered and how much to learn. Bottom.

“We understood the physiology of the senses, but we didn’t understand how we perceived the temperature and pressure difference,” said Marin. “It is fundamental to know how our body perceives these changes, because if we know these molecules, we can use them in a targeted manner. It’s like finding a lock. And now I know the exact key needed to unlock it. “

Marin predicted that new pain treatments would likely come first, but once scientists understand how to reduce pressure on blood vessels and other organs, how can the body detect changes in pressure. Understanding can ultimately lead to drugs for heart disease.

Richard Harris of the University of Michigan’s Center for Chronic Pain and Fatigue Research also said the new winner’s research could help develop new analgesics, but said the area had long since stalled.

He said that pain also has a psychological component, so understanding how pain is caused in the body is not always enough to manage it. Still, the work of Julius and Patapoutian doctors will likely help better manage pain caused by extreme temperatures and chemical burns, he said.

“Your results give us some initial clues as to how this type of pain begins, but we still don’t know if it’s relevant to many chronic pain patients,” he said.

Still, University of Sheffield pain expert Fiona Boissonnard said the work of Nobel Prize winners is particularly relevant to one in five people in the world who suffer from chronic pain.

Pains like arthritis, migraines and chronic back pain are “major medical problems and completely inadequately treated,” she said. “Their studies could lead to the identification of new compounds that are effective in treating pain without the disastrous effects of opioids,” sparking an addiction crisis in the United States.

Following a long tradition that it is difficult to warn Nobel Prize winners, Julius said he woke up to what he believed to be a prank phone call shortly before the award ceremony.

“My phone made a kind of buzzer from a relative who was contacted by someone on the Nobel Committee trying to find my phone number,” he said from his San Francisco home.

It was only when his wife heard Pearlman’s voice and realized it was not a joke that he confirmed that he was the secretary-general of the commission. Julius said his wife worked with Pearlman many years ago.

Julius, 65, later stated that he hoped his work would lead to the development of new pain relievers and stated that the biology behind everyday activities could be very important. Bottom.

“We eat chilli and menthol, but often we don’t think about how it works,” he says.

The Nobel Committee tweeted a photo of Patapoutian in bed with his son while Pataptian looked at the announcement on his computer.

Born in Lebanon, Patapoutian said, “Thank you. This country has given me the opportunity to have great training and support for basic research and for my researchers and staff with me. You worked with me. “

The prestigious award comes with a gold medal and SEK 10 million (over $ 1.14 million). The award is a legacy of the Swedish inventor Alfred Nobel, the creator of the award, who died in 1895.

This is the first time that this prize is awarded. Further awards are given for outstanding achievements in the fields of physics, chemistry, literature, peace and economics.

___

Chen reported from London. Associated Press author Frank Jordan contributed from Berlin.

2 win Nobel Medicine Awards for how we react to heat and touch Source link 2 win Nobel Medicine Awards because they show how we react to heat and touch