Figure 1. Scheme of the experimental procedure. BIA, body impedance analysis; CK, creatine kinase; MVIC, Maximum Voluntary Isometric Contraction for Peak Force; DOMS, delayed onset of muscle soreness via visual analog scale; RM, repetition maximum; and EIMD, exercise-induced muscle damage. The second visit combines both pre- and post-measurements, immediately before and after the EIMD stimulus, respectively. Photo credit:

Researchers at the University of Westminster have found that in healthy men, after intense exercise, small pieces of cells are released that play a role in cell-cell communication.

The results suggest that the release of these tiny pieces of cells known as extracellular vesicles (EVs) serve as an indicator of subsequent muscle damage and may play a role in strategies to reduce the effects of exercise-induced muscle damage (EIMD). in people.

EVs are naturally released from cells of origin; they are found in blood and other body fluids and participate in cellular communication through the systemic transfer of protein charges and genetic material between cells throughout the body.

The researchers show that physical responses to high-intensity resistance exercise stimulate EV changes in the blood that correlate with subsequent known markers of muscle damage. The EV release profile after intense exercise could thus play a role in the EIMD response in humans.

Previous research on EV profiles has largely focused on human pathologies, including cancer and autoimmune diseases, or EVs have been studied in small animal models. To date, no studies have examined the effects of high-intensity resistance training or the effect of aging on circulating EV profiles after vigorous resistance training. The results presented in this study are the first to apply these findings to human models of muscle damage – particularly healthy, physically active, younger and older men.

The study was carried out by the Translational Physiology Research Group in collaboration with the Tissue Architecture & Regeneration Research Group of the School of Life Sciences.

Speaking of study, Ph.D. Researcher and lead author Yvoni Kyriakidou said, “Research has shown that skeletal muscles can release EVs into the circulation even after a training session. However, the potential role of EV, including as a putative biomarker of muscle damage, remains unclear. We show that exercise-induced EV release profiles can serve as an indicator of subsequent muscle damage. “

“If the post-exercise EV response does indeed reflect physiological recovery responses from injury, the extent and content of the EV profile changes could be of interest in strategies to reduce the debilitating effects of EIMD.”

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More information:
Yvoni Kyriakidou et al., Preliminary Investigations Into the Effect of Exercise-Induced Muscle Damage on Systemic Extracellular Vesicle Release in Trained Younger and Older Men, Frontiers in Physiology, September 24, 2021. Provided by
University of Westminster

In healthy men, small pieces of cells are released after exercise, a possible indication of muscle damage (2021, September 24)
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