Relationship Between Serum Lipid Levels and Severe Headache or Migraine in a Representative American Population: A Cross-Sectional Study

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Curr Neurovasc Res. 2021 Sep. 23. doi: 10.2174 / 1567202618666210923145635. Online before printing.


BACKGROUND: The relationship between serum lipids and migraines remains controversial.

OBJECTIVE: This study aimed to analyze the association between serum lipids and severe headaches or migraines in the general population.

METHOD: The data were collected from a nationally representative sample of participants in the National Health and Nutrition Examination Survey from 1999 to 2004. The interviewers recorded self-reported severe headaches or migraines and whether the pain persisted for more than 24 hours in three months. A weighted general linear model was used to estimate the relationship between serum lipids and severe headaches or migraines. Regression analyzes were performed after adjusting for age, gender, race, energy intake, sodium intake, etc. Subgroup analyzes were performed using the same regression model.

RESULTS: We included 5,937 people with a weighted mean age of 45.8 years. Men made up 47.6% of the participants. After adjusting for covariates, a non-significant association between migraine and total cholesterol (odds ratio = 0.96, 95% confidence interval = 0.85; 1.05; P = 0.32), low-density lipoprotein cholesterol (odds ratio = 0 , 96; 95% confidence interval = 0.75, 1.17, P = 0.55) and high-density lipoprotein cholesterol (odds ratio = 0.99; 95% confidence interval = 0.49, 1.59, P. = 0.58) in the continuous form. In subgroup analyzes, no significant association was found between total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and self-reported severe headaches or migraines.

CONCLUSION: When adjusted for covariates, total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol were not significantly associated with severe headaches or migraines in the general American population. There is insufficient information to support the measurement of common serum lipids in general headaches and migraines.

PMID: 34561979 | DOI: 10.2174 / 1567202618666210923145635