The body secretes insulin to help regulate blood sugar levels by helping other cells in the body absorb glucose. Type 2 diabetes is when cells become resistant to insulin, the hormone that regulates blood sugar levels by helping other cells in the body take up glucose for energy. If left untreated, the disease can significantly increase the risk of serious cardiovascular disease. However, a throbbing pain that many experience can protect against type 2 diabetes.
However, the same peptides are found in the pancreas along with another peptide called amylin and can affect the release of insulin from beta cells.
When the cells in type 2 diabetes become resistant to insulin and are less able to take up glucose, the beta cells increase insulin production compensate.
to To further study the role of the peptides, Dos’s team at the University of Tennessee developed a new method to collect data from cells that showed that the peptides lowered insulin levels in mice.
They believe that the peptides could therefore counteract the insulin resistance that develops in type 2 diabetes.
Do added, “Despite these positive results, you cannot inject the body with the CGRP and PACAP peptides as therapeutic strategies for diabetes as these little ones cause migraines.
“But once we understand how they affect insulin secretion, we can develop peptide analogues that control insulin but do not bind to the pain receptor.
“It is believed that the CGRP and PCAP peptides each play a unique protective role against type 2 diabetes.
In particular, CGRP restricts insulin and amylin production, which could protect cells and normalize their function.
PACAP, on the other hand, could regulate insulin and promote the multiplication of beta cells, according to the team’s analysis.
In addition, various anti-CGRP and anti-PACAP treatments are currently in development or already on the market for migraines.
It is feared that this could increase the risk of diabetes.
However, the team continues to hope that their results will provide targets for therapies that may help prevent type 2 diabetes.