https://www.fapjunk.com https://pornohit.net london escort london escorts buy instagram followers buy tiktok followers Ankara Escort Cialis Cialis 20 Mg

They don’t absorb all of the salt in a saltwater hot tub

0

Dear Doctor. roaches, I wonder if the claims made by saltwater hot tub manufacturers about the health benefits are factual.

My blood pressure was high and my doctor recommended that I watch my salt intake. After reading the labels on foods, the sodium was very significant in most items. Since then I can drop it but it’s still a bit high.

I use a salt water hot tub and am wondering if salt is absorbed through the skin and how much this would increase blood pressure.

—DB

Dear DB: Oftentimes, what appear to be health claims – whether they’re about dietary supplements, vitamins, or devices – are followed by the words, “These claims have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.” (Sometimes the writing is very small, but if you look for it you will find it.) When you see this statement, rest assured that it is there is no strong evidence that there is any value in what they are trying to sell you. However, there may still be health benefits that have not yet been proven.

In the case of hot tubs and saunas, some of the suggested subjective benefits include stress relief, muscle relaxation, and pain relief. Most people who enjoy hot tubs are likely to reap these benefits. There is weak evidence that regular hot tub use may improve diabetes control and preliminary evidence that it may benefit cardiovascular health. While large studies have shown that people who use saunas or hot tubs have longer lifespans, it is by no means clear that the heat treatments produce the observed benefits.

I can tell you that salt doesn’t get absorbed through the skin in any appreciable amount, so don’t worry about that. You will benefit much more if you eliminate some of the high-sodium foods from your diet.

DEAR DOCTOR. Roach: I suffer from dizziness. I went to an otolaryngologist and was diagnosed with Meniere’s disease. However, I occasionally have neck pain and a hump in my neck. A friend suggested I see a chiropractor for adjustments. Could what the chiropractor is treating possibly be the cause of my vertigo problems?

— MC

Dear MC: Meniere’s disease is a cause of vertigo (a feeling like spinning when a person isn’t moving), along with hearing loss and tinnitus (a perceived sound like a ringing when there really is no sound). Meniere’s disease is caused by a buildup of fluid in the inner ear.

Spinal manipulation such as B. chiropractic manipulation, provides immediate pain relief that was superior to drugs but not as effective as home exercise. I could find no convincing evidence that any type of spinal manipulation would be effective in Meniere’s disease, and no reason to believe that it would.

I’m not sure what you mean by a hump on the back of the neck. We all have a protrusion in the seventh neck bone, but it’s possible that you have kyphosis, which should be checked out by your GP.

Standard treatment for Meniere’s disease includes a low-sodium diet, caution with caffeine and alcohol, and vestibular rehabilitation (a series of exercises supervised by a specially trained physical or occupational therapist). These have been shown to reduce symptoms of imbalance. Some people benefit from medications to reduce fluid buildup in the inner ear, such as B. Diuretics.

Readers can email questions to [email protected].

The clinic that treats you all

0
The clinic that treats you all

Photo / Included.

The New Habit Health Clinic in Petone is now practicing all-round treatment.

Penny Collins could tell right away that this was more than a physical injury. The man had a below-knee amputation, but it was clear his confidence and mental health were also affected.

Collins, senior physical therapist at Habit Health Petone, asked the center’s broader team for their medical expertise to help him.

Collins is glad he came to her clinic. It’s a bit different – sort of a one-stop shop where a wider range of healthcare can be provided based on your needs. This format allows healthcare professionals like her to build relationships with patients, build trust and help them in many aspects of their lives.

“I could see we could really help this guy, but he needed someone to see the whole picture,” she says. “Recovering from an injury isn’t just physical, very often there are mental and emotional barriers to getting better. That’s what our team looks at – the customer as a whole.

“We organized a psychologist from our team to help him deal with his mental stress from his injury. We also noticed that his hip was quite weak, so a physiotherapist started working on that as well. What we’re proud of.” is the fact that he didn’t have to explain anything more than once.

“Now he has been fired from our psychologist for regaining his confidence and we are at a point in his rehabilitation where he is only working with a careers counselor to help him find work. It’s great to see how far he’s come.”

Petone is the latest addition to Habit Health’s clinics across New Zealand to practice this holistic approach – meaning people’s hurts or concerns are not treated in isolation: “We look at all barriers to well-being so we can look at them as a whole person,” says Collins.

This works because of Habit Health’s internal referral process, which allows the broader healthcare team to be much more responsive to people’s needs. It’s also much more convenient for clients who don’t have to go from one clinic to the next. For example, the Habit Health Petone team includes physical therapists, occupational therapists, a psychologist, social workers, nurses and careers counselors.

How does this “holistic” approach actually benefit customers? “It makes their lives a lot easier,” says Collins. “Life shouldn’t be that hard, especially when you have a bad injury. You shouldn’t have to run across town to see different people for different things.”

It’s not just about seeing the physical therapist, she says. The physical therapist can help with the onset of neck pain – but then the patient can consult one of Habit Health’s counselors about the stress in their life that is causing the neck pain.

With the team under one roof, the healthcare team can get much-needed information about clients and sequentially book appointments with other healthcare professionals.

Photo / Included. Photo / Included.

“Patients don’t have to go somewhere else and explain everything over and over again. The information is all here and we’re all in one place.”

Collins believes health is far more complex than just treating people from one angle, with mental and emotional aspects of life being extremely important to overall well-being: “The social stuff is huge. We have a social worker who was helping a mother with an injured back I was helping her with her back but the social worker was helping her gain confidence as this mother was also coping with some of the anxiety from the injury.

“Our social worker helped her join a local mothers group and did everything she could for this woman. I helped her with physical therapy but sometimes people just need to talk before we can even get to the injury.”

Habit Health is also focused on using cutting-edge technology to help people recover faster. “It’s great to see our Petone team keeping up with the latest techniques,” says Collins. “We use the Canadian GaitScan system as part of the treatment. It performs a full assessment of your biomechanics, capable of capturing a whole range of injuries that people may not be aware of.”

She encourages people to actively take care of their health instead of ignoring problems: “I hate hearing about people who endure things when they don’t have to – like a mother who endures carpal tunnel syndrome in her hand, if only she has to stretch her shoulders from holding her baby in the cradle for six months.”

The biggest rewards Collins wins come from helping people with severe headaches and migraines “because they can be so painful and debilitating.”

“People need to understand that any pain that has existed for a long time is really built into your system. Persistent and chronic pain is a real focus for us here because we believe we can transform people’s lives and attitudes. When it’s bad, it keeps people from living their lives to the fullest.

“When we help people, we can see them start smiling, relaxing and laughing again. It’s just wonderful to be a part of it.”

For further information, click here.

These premium gel pads are on sale!

0
Yahoo Life US

We may receive commissions for purchases made through links on this site. Prices and availability are subject to change.

SUPPORTIVE AND COOLING – So you can relax while you rest and wake up pain free. (Photo: Walmart)

Even if we wash our linens regularly, our pillows still need to be replaced fairly frequently. They should actually be replaced every one to two years, otherwise they not only lose their shape, but also no longer offer the necessary support for the head, neck and shoulders. As soon as the neck pain creeps in, you know it’s time. And admit it: you probably know that it’s long gone at the moment.

No worries. We spotted these 2-pack Rest Haven gel memory foam pillows on sale at Walmart, and they’re just too good to pass up. Fresh, clean, and supportive, they allow you to get the kind of deep sleep your body needs for overall well-being. With this offer, the king set is only $30 per pillow, and the standard or queen pack is only $27.50 per pillow.

Do you want to save even more? Make sure you’re signed in to Walmart+. It’s as simple as signing up for your free 30-day trial here, and a short three-question survey extends another two weeks for a solid 30-day usage. (And by the way, those without Walmart+ still get free shipping on orders $35 or more.)

$60 $67 at Walmart

Doesn't your neck feel better just looking at these?  (Photo: Walmart.com)

Doesn’t your neck feel better just looking at these? (Photo: Walmart)

Memory foam for support and comfort

These pillows are made entirely of cozy memory foam, which makes them not only soft to the touch, but firm enough to offer plenty of support. It cradles your neck, head and shoulders and helps relieve pressure in those areas.

“I haven’t slept this well in a long time,” explained one shopper. “An out of this world comfort. Throw away all those $5 pillows and buy this, you will see the difference from the first night, the neck pain I had has miraculously gone! Today I feel strong and full of energy!”

Cooling gel prevents welding head formation

Hate waking up in the middle of the night in a sweat? With this pillow, you don’t have to constantly flip over to the cool side – both sides are designed to stay cool. All of this is thanks to the cooling gel woven throughout the pillow that helps keep your body temperature down.

It also doesn’t trap hot air: the ventilated design allows for plenty of breathability and airflow.

Loved by picky buyers

These pillows have no shortage of fans – over 800 buyers gave them perfect five-star ratings.

One shopper who recently had neck surgery gushed about the cloud-like support of Rest Haven’s gel memory foam pillow: “The first night I put my head on it, all my fears that it wasn’t enough went away could offer support! My head and neck felt like I was being cradled on a soft fluffy cloud and I woke up with no neck pain after a full eight hours of sleep! I usually only get about five or six hours of sleep if I’m lucky. I posed also states that this gel’s enriched memory foam was just what I needed for my fibromyalgia as it didn’t put undue pressure on my head and neck. This pillow is now my absolute favorite!!”

Another self-proclaimed “Pillow Goldilocks” agreed: “The gel keeps the pillow nice and cool. The memory shape helps to conform to your head so it really becomes what you need. I’ve gotten the best, most restful sleep I’ve had since using it. I cannot recommend this pillow enough. Get one so you can enjoy a full night’s sleep!”

Doctors say that good sleep is one of the best things you can do for your mind, body and spirit. Take advantage of this sale to enhance your nighttime experience and give your body the rest it needs – and a pain-free wake-up call in the morning. It’s the kind of small changes that can make a big difference.

$60 $67 at Walmart

Looking for more great Walmart deals? Check out these:

TV offers:

Vacuum Offers:

  • Shark RV2001 AI Robot Vacuum, $380 (was $480), walmart.com

  • Shark Navigator Anti-Allergen Upright Vacuum, $129 (was $144), walmart.com

  • Shark Steam Mop, $39 (was $59), walmart.com

  • Ionvac Smartclean 2000 Robovac, $97 (was $180), walmart.com

  • IonVac HydraClean cordless all-in-one wet/dry vacuum, $144 (was $399), walmart.com

  • Bissell CrossWave All-in-One Multi-Surface Wet-Dry Vac, $199 (was $249), walmart.com

Headphones and Earbuds Deals:

Linen Deals:

  • Serta So Cozy 5-Piece Sherpa Reverse Comforter Set, $25 (was $45), walmart.com

  • VCNY Home Damask 7 Piece Duvet Set, $35 (was $60), walmart.com

  • Tempur-Pedic Memory Foam Essential Support Pillow, $45 (was $79), walmart.com

  • Rest Haven 2-inch Convoluted Gel Memory Foam Topper and Shredded Memory Foam Pillow, $42 (was $50), walmart.com

  • Mellanni Plush Gel-Fiber Filled Pillows King 2-pack, $45 (was $60), walmart.com

Video Game Deals:

  • Best Choice Products 360-degree rotating gaming floor chair, $100 (was $150), walmart.com

  • Novashion gaming keyboard and mouse combo with headset, $50 (was $71), walmart.com

  • LucidSound LS25BK Wired Stereo Gaming Headset, $60 (was $80), walmart.com

  • Rig 500 PRO HX SE White Gaming Headset for Xbox, $49 (was $70), walmart.com

  • Mortal Kombat XL for PS4, $18 (was $30), walmart.com

Smart Home Offers:

  • Energizer Connect smart plug, no hub required, $20 (was $50), walmart.com

  • Philips Hue White E26 Smart Bulb 2-pack, $80, (was $90), walmart.com

  • Wonderful Home Security Network, $50 (was $100), walmart.com

  • Velocity Smart Wifi LED Light Bulb for Amazon Alexa/Google Home, $12 (was $48), walmart.com

  • Roku Express HD streaming player with HDMI cable and remote control, $24 (was $29), walmart.com

Kitchen offers:

  • Ninja Foodi TenderCrisp 8-in-1 6.5-Quart Pressure Cooker, $139 was $229, walmart.com

  • Drew Barrymore’s beautiful high-performance touchscreen blender, $55 (was $66), walmart.com

  • Gpeds 30-piece utensil set, $40 (was $110), walmart.com

  • PowerXL Grill Air Fryer Home, $69 (was $149), walmart.com

  • Nutribullet Select Blender, $50 (was $100), walmart.com

  • George Foreman 15+ Serving Indoor/Outdoor Electric Grill, $79 (was $100), walmart.com

Fashion Offers:

  • Free Assembly’s Long-Sleeve Boyfriend Shirt, $11 (was $22), walmart.com

  • LC Sterling Silver Pear Garnet Earrings and Stainless Steel Chain Necklace, $32 (was $40), walmart.com

  • Athletic Works Soft Jogger Pants, $9 (was $13), walmart.com

  • Bulova Ladies Mother-of-Pearl-Diamond-Dial Watch, $175 (was $350), walmart.com

  • The Get Women’s Tie Neck Poet Sleeve Blouse, $9 (was $28), walmart.com

  • Women’s 1/2 ct diamond x hoop earrings, $30 (was $61), walmart.com

  • Peermont Lab created fire opal and 18k white gold stud earrings, $20 (was $110), walmart.com

Beauty offers:

  • InfinitiPRO by Conair Gold Hot Comb, $20 (was $50), walmart.com

  • Maybelline Color Sensational Cream Finish Lipstick Makeup in Pink & Proper, $6 (was $8), walmart.com

  • Shany Carry All Makeup Set, $40 (was $80), walmart.com

  • Peter Thomas Roth Pumpkin Enzyme Face Mask, $33 (was $60), walmart.com

  • Newway 15/20 piece makeup brush set, $10 (was $20), walmart.com

  • EleaEleanor 60 Color Makeup Palette, $24 (was $86), walmart.com

Health and Wellness:

  • Skonyon adjustable dumbbells, 1 pair, $95 (was $140), walmart.com

  • Spawn Fitness Fabric Resistance Bands Set of 3, $19 (was $39), walmart.com

  • Germ-X ​​Advanced Hand Sanitizer, $3 (was $4), walmart.com

  • Hand Sanitizing Gel 4-pack, $15 (was $30), walmart.com

  • Lysol Disinfectant Spray, $5 (was $10), walmart.com

Read more from Yahoo Life:

follow us on Instagram, Facebook, Twitter and Pinterest for non-stop inspiration, delivered fresh to your feed every day.

Want daily pop culture news delivered to your inbox? Sign up here for the Yahoo Entertainment & Life newsletter.

Docklands, get more mobile this March

0
Docklands, get more mobile this March

March is “Mobility Month” and as your local chiropractor, I urge all Docklands residents to test their flexibility and mobility and protect their spine health.

A staggering three-quarters (72.2 percent) of people who have had to work from home suffered from postural pain — now chiropractors across the country want to make sure the damage doesn’t last.

Spinal problems can go beyond physical pain. A third (32.6%) of Aussies living with pain admit it affects their mobility and one in five (20.7%) say it causes anxiety and depression. Experts say four simple test exercises could determine the state of your spine’s health and whether you need to seek professional help.

During this Mobility Month, as Docklanders approach the two-year anniversary of the “new normal,” Dr. Mike of Docklands Health gave Docklands locals a chance to assess their spine health and mobility with a simple four-step test.

Over the past two years, I and other chiropractors across the country have seen a worrying increase in patients reporting back and neck pain caused by changes in their lifestyle — such as working from home rather than in the being able to exercise. Therefore, we would like to encourage everyone to proactively check their mobility and protect their health and well-being.

According to research, a third of people living with pain (such as neck and back pain) admitted to having limited movement and mobility (32.6 percent), which has significantly impacted their quality of life. For example, one in ten (11.5 percent) admitted that they were no longer able to play with their children, and 11.8 percent of the candidates also said that this “restricted mobility” affected their ability to have intimate relationships (11 .8 percent). .

However, mobility issues can go much further than just highlighting spinal pain and can often point to a range of significantly more serious health problems. For example, research shows that people with a sedentary lifestyle and postural pain double their risk of cardiovascular disease, diabetes and obesity, and increase their risk of colon cancer, high blood pressure, osteoporosis, dyslipidemia, depression and anxiety.

Mobility Month is the perfect time to give yourself a movement assessment, determine if your body isn’t as mobile as it could be and seek professional advice if needed.

To help porters assess their mobility and ensure they are at risk of serious health consequences, a few simple tests have been developed to try at home •

3 signs it’s time for a new pair of glasses

0
3 signs it's time for a new pair of glasses

“Don’t let your eyes pay the price for too much screen time,” he says Katy Hanson, CMO of Eyemart Express. “A visit to the eye doctor and a new pair of glasses can improve your vision and make everyday tasks a whole new experience, no matter where you work.”

3 signs you need new glasses:

  1. Severe Eyestrain and Eye Fatigue: Neck pain, headaches, and dry eyes are all signs that the eyes are getting tired and may need correction. After getting a new prescription from an eye doctor, try lens treatments like UltraXBlu to filter harmful blue light from digital screens for added protection.
  2. Vision changes: Any changes in your vision, such as blurry vision or squinting to see clearly, are key indicators that it’s time for an eye exam. Most likely, new glasses with an updated lens power will do. See clearer faster with Eyemart Express with same-day eyewear thanks to the on-site retailer’s lens labs.
  3. Time in the sun: Prolonged sun exposure from jobs that require extended periods of time outdoors, like delivery drivers and waiters, can irritate eyes, according to The Vision Council. Get prescription sunglasses with a gray tint to reduce brightness and keep vision clear when traveling or working outdoors.

Visit an Eyemart Express to protect your eyes at work and keep them healthy for years to come.

About Eyemart Express
Eyemart Express (EyemartExpress.com) is a national optician retailer known for offering quality prescription eyewear with a focus on affordability and convenience. Eyemart Express is among the top 10 optical retailers in the country with its Vision 4 Less, Visionmart Express and Eyewear Express family of brands. The company is based in Farmers Branch, Texas, and has 238 stores in 42 states. Eyemart Express offers a solid frame selection for the whole family with more than 2,000 frames from brands like Ray-Ban, Coach, Nike and Disney. On-site lens labs and experienced lab technicians can deliver quality eyewear in as little as 30 minutes.

SOURCE Eyemart Express

February is heart health month

0
February is heart health month

Nell J Redfield Memorial Hospital and other Oneida County healthcare workers have joined forces to recognize and promote National Heart Health Month in February. The crew gathered on the hospital steps in their Heart Health shirts “just to remind people to live a heart-healthy life,” said Kathy Hubbard.

February is a month associated with colorful heart images. From pink cookies, cards and banners to ubiquitous advertising backdrops, the familiar shape is something of an icon of the month. But that also makes it a perfect time to remind people about cardiovascular health. According to the CDC and the National Institutes for Health, 800,000 Americans suffer a heart attack each year, and 600,000 die. In terms of all causes of death nationally, it accounts for one in four deaths, making it the leading cause of death in the United States and worldwide. Coronary artery disease (CHD) is the primary condition leading to heart attacks.

The average human heart weighs between 8 and 12 ounces. Despite its relatively small size, it has enough power to pump blood around the body 60-80 times per minute, creating the flow of blood that carries oxygen and nutrients to cells and removes toxins and waste. Heart disease is the result of a blockage in the arteries leading to the heart. Other heart diseases can be caused by a variety of diseases, drug use, and environmental toxins. Smoking, alcohol, stress, diabetes, inactivity and poor diet are usually cited as the most common contributors to heart attacks. Health officials also suggest that COVID-19 has been shown to be more deadly for individuals suffering from various forms of heart disease.

Heart attacks themselves vary in intensity. A report from the AHA suggests that “one in five heart attacks occurs without the person even knowing they’ve had one.” In many cases, the symptoms of a heart attack — which can include arm and neck pain, nausea, fatigue, shortness of breath, and vomiting — are dismissed as something less significant. This is especially true for women under the age of 50, who are twice as likely to die from heart attacks as men in the same demographic.

While there is no single method to ensure heart health, there are some general guidelines that have been shown to support heart health:

• Exercise – Most medical organizations, including the American Heart Association and the National Institutes for Health, agree that the most effective and important factor in heart health is staying active and moving. While all aerobic activity can dramatically improve heart health, walking has been shown to be just as effective as most high-intensity exercise and easy to practice. Pedometers and smart watches can be helpful for creating a consistent walking program and monitoring progress, but all walking is positive when it comes to getting your heart stronger.

• Diet – The word “diet” is considered problematic by many health authorities because it usually implies a focus on the visual results of weight loss or quick “gimmick” plans for quick weight loss. Diet, on the other hand, emphasizes a healthy balance of foods and materials ingested. Empty calories, such as those from soda pop or junk food, tend to increase the buildup of fat cells and cholesterol, which can lead to a buildup of plaque in the arteries and a greater workload on the heart. Simple substitutions such as B. a glass of water with a lemonade during the day can make a noticeable change.

• Testing – Experts emphasize the importance of regular screening to detect developing or emerging heart health problems. Cholesterol and blood pressure checks are easy to do and can often be done at home. Prediabetes can be caught early enough to prevent the development of full-blown diabetes, which can be an important factor in heart health.

As every year, the President signed a proclamation declaring February as American Heart Month. In the statement, he wrote: “Continuing the fight against cardiovascular disease is critical to improving our nation’s public health. During American Heart Month, we must renew our commitment to ensure a healthier future for all Americans.”

EP REVIEW: Violence – Let the World Burn

0
EP REVIEW: Violence - Let the World Burn

Bay area thrashers force Maybe they’ve only been around for eight years, but what a great decade was at hand. From their classic hyper aggressive debut Eternal nightmare (MCA records) to the controversial lyrics of ‘Torture Tactics’ and a deliciously questionable vegetable soup and vinegar “puke bag” plastic record sleeve, the band also launched the career of a certain Robb Flynn which later formed the game changers of the 1990s machine headpossibly followed by a guitarist Phil Demmel. With three studio albums under their belt, the band went their separate ways in 1993 and only became a full-time venture again in 2019.

Singer with a life-saving liver transplant Sean Killian a new life, it was time for Vio-Lence to return. Or at least three-fifths of it. With Demmel returning alongside the drummer Perry Stricklandthe original members turned to former members overkill guitarist Bobby Gustavson and exfear factory four-string Christian Olde Wolbers to restart the band let the world burn (metal blade) their first new release in almost thirty years.

Fueled by pinching squeaks and blisteringly fast riffing, “Flesh from Bone” takes off like a rocket, the opener being punctuated by Killian’s distinctive if occasionally divisive vocal delivery, which is even beginning to sound like it Hunter frontman Tom Araya in places. More razor-sharp aggression awaits with “Screaming Always,” a weighty track that takes on a slightly more relaxed approach in its groove-driven middle section. A bit reminiscent of “Nanking” from other Bay Area legends Exodus, “Upon Their Cross” is armed with oodles of low-end pitch-diving and whammy action, while the short sharp three-and-a-half-minute blast of “Gato Negro” is a fast and brutal jaunt into a sore neck. The title track closes the record with a riff so fast that even the most accomplished air guitarist is sure to get sore wrists afterwards.

So there you have it. After nearly three decades of absence, Vio-Lence has returned as if 1988 had been just last week. A stunning five track EP with the promise of another short form release in the future, let the world burn maybe just a temporary high, but it was more than worth the wait.

Buy the EP here: https://www.metalblade.com/violence/

8/10

GARY ALCOCK

MediciNova announces in the Global Spine Journal that MN-166 (ibudilast) has been identified as a potentially beneficial pharmacotherapy for the treatment of degenerative cervical myelopathy

0
MediciNova announces in the Global Spine Journal that MN-166 (ibudilast) has been identified as a potentially beneficial pharmacotherapy for the treatment of degenerative cervical myelopathy

MediciNova, Inc.

LA JOLLA, Calif., Feb. 28, 2022 (GLOBE NEWSWIRE) — MediciNova, Inc., a biopharmaceutical company traded on the NASDAQ Global Market (NASDAQ:MNOV) and the JASDAQ Market of the Tokyo Stock Exchange (code number: 4875) announced today that MN-166 (ibudilast) has been discussed in the Global Spine Journal as a potentially beneficial pharmacological agent for the treatment of degenerative cervical myelopathy (DCM).

The publication, entitled Developing Novel Therapies for Degenerative Cervical Myelopathy [AO Spine RECODE-DCM Research Priority Number 7]: Opportunities from Restorative Neurobiology” and co-authored by MediciNova’s collaborator Dr. Mark Kotter, Professor, Neurosurgery Unit, Department of Clinical Neuroscience, University of Cambridge, UK, and colleagues discussed contemporary therapies that may have therapeutic value in three broad categories of neuroprotection, neuroregeneration and neuromodulation. Among those reviewed, the authors discuss the properties of MN-166 (Ibudilast) that support its use in DCM. The combination of the anti-inflammatory, neuroprotective, and neuroregenerative properties of MN-166 (ibudilast) is the basis for RECEDE myelopathy, a phase 3, double-blind, randomized, controlled study to evaluate its efficacy as an adjuvant treatment to decompression surgery in DCM on mJOA (modified Japanese Orthopedic Association) score and neck pain.

Key findings from the publication include:

  • Chronic spinal cord compression due to DCM leads to ischemia, neuroinflammation, demyelination, and neuronal loss.

  • People with DCM often develop lifelong disability and then suffer lifelong disability, with less than 5% fully recovering despite surgical decompression.

  • At the site of chronic spinal cord compression, an increase in activated microglia and macrophages has been observed, which is a source of pro-inflammatory cytokines and can lead to further cell death through necrosis and apoptosis.

  • MN-166 (Ibudilast) has been shown to exhibit central anti-inflammatory, neuroprotective and neurotrophic/neuroregenerative effects through inhibition of phosphodiesterase (PDE4 and PDE10) and macrophage migration inhibitory factor (MIF).

  • This combination of effects, resulting in a decrease in glial activation and an increase in neurotrophic/neuroregenerative factors, is a compelling reason to evaluate MN-166 (ibudilast) for the treatment of DCM.

  • MN-166 (ibudilast) is the only drug currently being evaluated in Phase 3 as a regenerative medicine for the treatment of DCM.

The story goes on

Kazuko Matsuda, MD, PhD, MPH, Chief Medical Officer of MediciNova, Inc., commented, “We are encouraged that MN-166 (ibudilast) has been identified by this highly respected research team as a potentially beneficial pharmacotherapy for the treatment of DCM , a disease from which very few patients fully recover.”

About AO Spine RECODE-DCM Research Priority 7

The AO Spine RECODE-DCM is an international initiative to create a “research toolkit” to accelerate knowledge, discovery and outcomes in degenerative cervical myelopathy. It has 10 research priorities. The seventh of these is defined as “Advanced Therapies”. This article is published as part of a series of AO Spine RECODE-DCM reviews presented in the Global Spine Journal.

About degenerative cervical myelopathy

According to Myelopathy.org, degenerative cervical myelopathy (DCM) is defined as compression of the spinal cord in the neck that can lead to paralysis. DCM is a common, progressive neurological disease caused by aging, arthritis, and degenerative spinal diseases such as spinal stenosis and central disc herniation. According to the American Association of Neurological Surgeons, more than 200,000 cervical surgeries are performed each year to relieve spinal cord or nerve root compression. Compression of spinal nerves results in neurological dysfunction such as numbness, tingling, pain and stiffness in the neck, and pain and numbness in the arms, fingers, or hands. Patients may experience muscular abnormalities, including but not limited to balance and walking problems, incoordination, muscle weakness in the arms, shoulders, or hands, rhythmic muscle spasms, stiff muscles, muscle wasting, overactive reflexes, and loss of bladder and bowel control. Depending on the severity of symptoms, options for treating DCM include a restraining collar, physical therapy, pain medication, muscle relaxants, and surgery. There is currently no cure and no approved drug to treat DCM.

Via MN-166 (Ibudilast)

MN-166 (Ibudilast) is a small molecule compound that inhibits phosphodiesterase type 4 (PDE4) and inflammatory cytokines, including macrophage migration inhibitory factor (MIF). It is in late-stage clinical development for the treatment of neurodegenerative diseases such as ALS (amyotrophic lateral sclerosis), progressive MS (multiple sclerosis) and DCM (degenerative cervical myelopathy); and for glioblastoma, CIPN (chemotherapy-induced peripheral neuropathy) and substance use disorder. In addition, MN-166 (ibudilast) is being studied in patients at risk of developing acute respiratory distress syndrome (ARDS).

About MediciNova

MediciNova, Inc. is a clinical-stage biopharmaceutical company developing a broad pipeline of novel small molecule therapies for late-stage inflammatory, fibrotic and neurodegenerative diseases. Based on two compounds, MN-166 (ibudilast) and MN-001 (tipelukast), with multiple mechanisms of action and strong safety profiles, MediciNova has 11 programs in clinical development. MediciNova’s lead compound, MN-166 (ibudilast), is currently in Phase 3 for amyotrophic lateral sclerosis (ALS) and degenerative cervical myelopathy (DCM) and is ready for Phase 3 for progressive multiple sclerosis (MS). MN-166 (ibudilast) is also being investigated in phase 2 studies in glioblastoma, patients at risk for developing acute respiratory distress syndrome (ARDS) and substance dependence. MN-001 (tipelukast) has been evaluated in a Phase 2 study in idiopathic pulmonary fibrosis (IPF) and is in preparation for a second Phase 2 study in nonalcoholic steatohepatitis (NASH). MediciNova has a strong track record of securing investigator-sponsored clinical trials funded by government grants.

Statements in this press release that are not historical in nature constitute forward-looking statements within the meaning of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. These forward-looking statements include, without limitation, statements regarding the future performance and effectiveness of MN- 166, MN-001, MN-221 and MN-029. These forward-looking statements may be preceded, followed, or otherwise contained by the words “believe”, “expect”, “anticipate”, “intend”, “estimate”, “project”, “may”, “could”. may”, “will”, “would”, “considers”, “plans” or similar expressions. These forward-looking statements involve a number of risks and uncertainties that could cause actual results or events to differ materially from those expressed or implied by such forward-looking statements. Factors that could cause actual results or events to differ materially from those expressed or implied by these forward-looking statements include, among others, the risk of obtaining future partners or funding for the development of MN-166, MN-001 , MN-221 and MN-029 and risks of raising sufficient capital if necessary to fund MediciNova’s operations and contribution to clinical development, risks and uncertainties associated with clinical trials, including potential costs , the expected timing and risks associated with clinical trials designed to meet the requirements of the FDA guidelines and the feasibility of further development taking into account these factors, product development and commercialization risks, the uncertainty of whether clinical trial results will meet the Results i n later stages of product development, the risk of delays or failure to obtain or maintain regulatory approval, risks associated with reliance on third parties to sponsor and fund clinical trials, risks related to Intel intellectual property rights in product candidates and the ability to defend and enforce these intellectual property rights, the risk of failure of the third parties on which MediciNova relies to conduct its clinical trials and manufacture its product candidates to perform as expected, the risk of increased costs and delays due to Delays in the initiation, registration, completion or analysis of clinical trials or significant issues related to the adequacy of clinical trial design or conduct of clinical trials and the timing of expected regulatory submissions, ie e MediciNova’s collaboration with third parties, the availability of funds to execute product development plans and MediciNova’s ability to obtain third-party funding for programs and to raise sufficient capital when needed, and the other risks and uncertainties inherent in MediciNova’s securities and Exchange Commission filings, including the annual report on Form 10-K for the year ended December 31, 202 1 and its subsequent periodic reports on Form 10-Q and current reports on Form 8-K. Undue reliance should not be placed on these forward-looking statements, which speak only as of the date of this release. MediciNova disclaims any intention or obligation to revise or update these forward-looking statements.

INVESTOR CONTACT:

Geoff O’Brien

Vice President

MediciNova, Inc.

[email protected]

Cogir from Vacaville Senior Living

0

The newest facility to join the Cogir of Vacaville Senior Living Community is ONR – Orthopedic Neurological Rehabilitation.

ONR’s team includes a diverse network of therapists and industry professionals with a goal-oriented mindset to understand residents’ issues and drive rehabilitation solutions so residents can age in place.

ONR’s goal is for each individual to achieve the best possible quality of life through a range of activities to stretch the mind and body.

This program is available to qualified residents Monday through Friday and for as long as is medically necessary for the resident’s needs. Inquire about covered services today by calling 833-674-1981.

Cogir of Vacaville Rehabilitation Services can help with Arthritic Pain, Back & Neck Pain, Balance/Gaiting Difficulties, Cardiac/Respiratory Problems, Communication & Swallowing Difficulties, Fall Reduction, Neurological Problems, Orthopedic Injuries, Osteoporosis, Parkinson’s Disease, Performing Everyday Activities and posture help training, pre- and post-operative rehabilitation and vestibular problems.

All benefits are covered by Medicare and most other insurance plans.

Residents looking for improved mobility, greater independence, and greater success in activities of daily living will enjoy the luxury of these on-site therapy services. With over 30 years of experience providing personalized and specialized therapeutic care, Cogir believes that life should be lived to the fullest at every stage. Pain, weakness, or limited mobility shouldn’t stop you from doing the things you love.

Runners-up: Paradise Valley Estates, Rockville Terrace Senior Living

Cogir from Vacaville Senior Living

In Vacaville: 799 Yellowstone Drive, Vacaville
Phone: 707-447-7496
Website: www.cogirofvacavilleseniorliving.com

What is the difference? A doctor explains

0
dr  Jesse Pace

Most people know doctors with “MD” after their name. But some doctors have “DO” as part of their title instead. So what is the difference between a DO (Doctor of Osteopathic Medicine) and an MD (Doctor of Medicine)?

What kind of training do DOs and MDs undergo?

Both a DO and MD attended medical school and are physicians. What is different is how they are trained. Currently, about 25% of medical students are pursuing a DO degree.

DOs and MDs can pursue careers in primary care (like family medicine or internal medicine) or in a specialty (like oncology, urology, or general surgery).

Both types of physicians are required to complete a four-year undergraduate degree followed by a four-year degree at an osteopathic medical school or medical school. After completing their medical studies, they must complete an internship and specialist training (on-the-job training). After the stay, they can apply for a scholarship to further their education in a special field.

MDs and DOs must pass a licensure exam to practice medicine.

What is the difference between a DO and an MD?

MDs are considered allopathic doctors. They are trained to treat and diagnose medical conditions using conventional tools such as prescription drugs, x-rays and surgery. Generally, MDs take a targeted approach to treatment by reviewing symptoms, making a diagnosis, and prescribing treatment according to that diagnosis.

DOs also use traditional medicine techniques to diagnose and treat their patients. But they have a strong focus on prevention and a holistic approach to health. That is, they see the body as integrated. For example, if you visit a doctor for abdominal pain, in addition to treating your symptoms, they can examine what is causing the pain and how you can prevent it.

Osteopathic doctors are taught that many diseases originate in, or cause symptoms in, the body’s musculoskeletal system (including the bones, muscles, and nerves). Because of this, they are trained to perform physical manipulations and adjustments to treat symptoms and illnesses. These methods (referred to as osteopathic manipulative treatment, or OMT) are designed to relieve tight muscles, back pain, neck pain, and other ailments.

Both MDs and DOs are trained to treat and diagnose medical conditions using conventional tools such as x-rays, surgery, and prescriptions. DOs are trained with the understanding that structure and function are related. In addition to traditional techniques, DOs receive additional training in osteopathic manipulative treatment, which can aid in the diagnosis and treatment of a variety of issues.

The difference between osteopathic doctors and naturopathic practitioners

It’s important to note that osteopathic physicians (DOs) are different from naturopathic practitioners. Naturopathic practitioners (also called naturopaths) use natural remedies to treat health problems. Naturopaths complete four years of college education but are not licensed to practice medicine.

Naturopaths focus on healing the body through lifestyle changes, stress management, food, herbs, and water. While a DO can also suggest these lifestyle changes, they have the authority to prescribe medication, perform surgery, or perform manipulation.

What to expect when you see a DO

When you see a DO, the exam may not be that different from one with an MD, but they may focus more on your holistic health, prevention, and manipulations.

Both types of doctors are trained to provide you with excellent care. If you have any questions about your health, consult your family doctor. To find a provider near you, visit www.pardeehospital.org.

dr Jesse Pace is a Family Medicine Physician at Pardee Family Medicine Associates Asheville.

American Chiropractors Directory and News