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The 5 Best Neuropathy Creams: What Is The Best Neuropathy Pain Relief Cream


Do you have neuropathy pain in your legs or hands? You may be thinking that there is nothing you can do about it, but this couldn’t be further from the truth. Neuropathy pain relief cream is a simple solution for many patients who are suffering from chronic nerve pain in their extremities. These creams are made up of ingredients like capsaicin and menthol, which provide an effective form of temporary relief and help to reduce inflammation as well. In this article, we will talk about some of the best neuropathies creams on the market today so that you can find one that is right for you!


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What Is Neuropathy Pain Relief Cream?

Analgesic Creams

A topical pain reliever is a nonprescription product applied to the body. These drugs contain capsaicin, an ingredient found in hot chili pepper seeds. It is thought that this substance may inhibit nerve cells from relaying pain signals back to the brain, thereby providing relief for minor pain that may be throbbing close to the surface of the skin.


Anesthetic Creams

By numbing the area where they are administered, these drugs relieve and block localized pain. Lidocaine is one of the ingredients found in these topical creams. Lidocaine patches can also relieve such pain, while EMLA cream (Eutectic Mixture of Local Anesthetics) is a common anesthetic cream that numbs your skin within an hour of application.


Neuropathy Pain Relief Cream vs Oral Supplements

You realize that your hands or feet feel tingly or slightly burning as a result of pain from neuropathy. It is most common for these areas, especially your feet, to be targeted first because the nerves connecting those extremities are the longest and are most easily damaged.


You can treat these symptoms with supplements, but you don’t know when they’ll start working or if they will cause side effects. It is possible to feel sleepy, dizzy, or simply lethargic when you take any oral medication.


Topical creams are easy to apply to the painful area and are typically more accepted by patients due to their painless nature.


There are so many products available for nerve pain relief at drug stores that it’s easy to be overwhelmed. All of them claim to have the same end goal, but different people have different preferences.


There are a number of non-prescription creams that can be used to ease peripheral neuropathy pain, such as some for muscle pain, joint pain, or back pain. The two most common ingredients in topical over-the-counter creams/ointments are capsaicin and herbs. In several pain relief creams, these ingredients are combined with others for effective nerve pain relief.


What Should I Look for in a Neuropathy Relief Cream?


Interestingly, capsaicin is a compound found in hot peppers, and it is also an effective pain reliever for people suffering from peripheral neuropathy. By reducing the nerve pain signals in your body, the slight burning sensation felt when capsaicin creams are applied temporarily eliminates nerve pain.


There are, however, some people who can’t tolerate capsaicin. Although it has proven to be an effective source of pain, some people aren’t able to handle the initial pain sensation.


Using pepper-based nerve pain relief cream on damaged, broken, irritated skin is not advised. Additionally, it is necessary to apply it several times a day for weeks before it begins to work.



Lidocaine blocks transmissions of pain signals along with the sensory nervous system and blocks them from reaching the brain. It is used for treating a range of injuries from insect bites to scrapes, and lidocaine creams and ointments instill a loss of sensation in localized areas of pain.


In studies, lidocaine in nerve pain relief cream was shown to provide pain relief. One study in 2017 showed that the use of topical lidocaine was effective for people suffering from peripheral neuropathic pain in whom oral treatments were ineffective or had adverse effects on their health.



Since ancient times, mint oils have been produced or derived from menthol, which is an organic compound. In addition to relieving mild pain, topically applied creams containing this substance are effective in combating peripheral neuropathy.


Researchers have found that menthol creams may be useful in treating chemotherapy-induced neuropathy since they are fast-acting, affordable, and easy to use and because they are non-drugs.


Several cancer centers have stated that menthol creams are effective topical treatments for peripheral neuropathy.



Using topical herbal products is another non prescription cream alternative. Anti-inflammatory and analgesic (relieve pain) properties are present in herbal products. Through a cooling sensation, they trick the brain into thinking your skin has changed temperature, thus reducing inflammation. The enlargement of blood vessels also allows for better oxygen and nutrient delivery, facilitating faster healing.


The use of herbs with such properties dates back thousands of years. Herbal medicine provides effective pain relief around the world, including in North America and South East Asia. Calendula flowers, balm of gilead, and clove oil are examples of herbs that possess such properties. Herbal effectiveness is difficult to deny when it stands the test of time.


What is The Best Neuropathy Pain Relief Cream: 5 Best Neuropathy Creams

Joint Mud

This topical cream can be used to alleviate pain associated with peripheral neuropathy. Other uses include treating severe skin irritation, bed sores, psoriasis, eczema, and poison ivy, dry scaly skin, stiff muscles, infected skin, abrasions, and ulcers.


Other natural ingredients in the topical neuropathy cream include avocado butter, aloe butter, tea tree oil, olive oil, and more. Vitamin E and rosemary extract are the most potent ingredients of topical neuropathy cream.


Nervex Neuropathy Pain Relief – Nervex Cream

Vita Sciences designed the cream methodically by combining topical vitamins and nutrients. Vitamin B12 is found in high concentrations in this cream. All these vitamins and nutrients work together to lessen symptoms and support synapse repair. Capsaicin, MSM, and cetyl myristo, vitamin E, and a extract of the Andrographis plant are just some ingredients found in this cream.


Because the cream contains moisturizers and antioxidants, it can easily absorb into the skin. Everything is natural, so there’s no smell. It has been clinically tested and is highly praised by peripheral neuropathy sufferers.


Insta-Relief DM Pain Relieving Cream

This soothing cream can provide instant nerve pain relief due to its soothing properties. Using topical neuropathy creams, hands, knees, legs, muscles, and hands will feel less tingling, burning, and numb.


The company states that its cream makes people feel more comfortable and healthy, restoring their lost comfort. Plant-derived ingredients give this cream its quick healing powers and provide instant relief. You can use it up to four times each day if you suffer from extreme nerve pain.


There is a cooling and calming effect to the cream. The Cream has been approved by the Food and Drug Administration (FDA) and the company claims that even doctors recommend using it for patients who suffer from nerve pain. Aside from relieving pain related to peripheral neuropathy, it can also be used by people with arthritis.


Nuturna Neuropathy Nerve ( neuropathy by nuturna)

The multi-purpose concentrate will increase your circulation and alleviate your skin problems. This fast-acting cream is formulated with arnica, MSM, tea tree oil, aloe vera, vitamin B6, and menthol, to moisturize, soothe, and reduce inflammation on the skin.


The concentrated formula in this product is highly effective and powerful. Utilizing it will awaken your nerves and make you feel so much better. Nerve pain is reduced at the source with the cream since it penetrates the skin deeply.


Nature Remedies by 100% Natural Products

The Nature Remedies by 100% Natural Products cream is an antiseptic that treats a variety of ailments.


You can use the cream to relieve nerve pain, psoriasis, eczema, poison ivy, dry and cracked skin, sore muscles, sore joints, insect bites, inflamed skin, and abrasions.


Natural vitamin E and rosemary extract are the main ingredients in the topical pain-relieving cream.


Beeswax, cocoa butter, shea butter, coconut oil, peppermint, avocado butter, aloe butter, tea tree oil, olive oil, and others are also natural ingredients found in the topical neuropathy cream.


The formula was developed by a former Burt’s Bees Associate. It was created by a professional who specializes in essential oils and plant extracts.


In the company’s statement, they state that the cream they offer for nerve pain is not yet FDA-approved and should not be used in treating, curing, or preventing diseases or medical conditions.


Key Takeaways

Several topical neuropathy creams in the market are promising anti-inflammatory properties and instant pain relief. These topical neuropathy creams are made to improve blood circulation and reduce nerve pain caused by peripheral neuropathy symptoms and are perfect for those experiencing nerve pain, especially in the hands and feet.


Many of these topical neuropathy creams have natural ingredients that provide this calm and cooling effect. Aside from relieving neuropathic pain, these creams are also perfect for those experiencing pain related to nerve damage, muscle weakness, muscle spasms. Ingredients such as chili, aloe vera, vitamin e, and shea butter also help lessen severe pain, extreme pain, chronic pain, painful numbness, and tingling sensations.


These topical creams are also perfect for those who have diabetic neuropathy and may have allergic reactions to oral pain relievers and steroid injections. Even those with healthy nerve function can use these creams to reduce pain.


Although these creams may alleviate neuropathy pain and are less likely to cause an allergic reaction than oral pain relievers, it is still best to seek professional medical advice before using any of these creams.

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