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Migraine Treatment Featured On Viewpoint With Dennis Quaid | news

  Migraine Treatment Featured On Viewpoint With Dennis Quaid |  news

MIAMI, June 17, 2021 / PRNewswire-PRWeb / – “Viewpoint” treats migraine treatments in a new segment with experienced actors Dennis Quaid fill in the role of host. Content for the segment is provided for the episode by content providers operating in the relevant fields. The post introduces health professionals at the forefront of migraine management plans to discuss advanced treatments for an ongoing problem that affects many.

Most people know someone who suffers from or suffers from migraines frequently. An estimated 1 billion people worldwide suffer from migraines. Migraines are neurological disorders that can cause multiple symptoms and are typically characterized by severe, debilitating headaches. Other symptoms may include vomiting, difficulty speaking, nausea, sensitivity to light and noise, and tingling or numbness.

There is no cure for migraines, but treatment options make the symptoms less severe and easier to manage. A doctor may recommend over-the-counter pain or migraine medications such as acetaminophen or NSAIDs, or daily prescription medications to help prevent and reduce the frequency of headaches. Lifestyle adjustments are among the top treatment options for reducing migraines, including managing stress and avoiding migraine triggers such as foods, additives, or odors.

Migraines can be crippling for many people and sometimes make daily tasks impossible, which is why Viewpoint is proud to use its platform to help spread awareness about the condition. The upcoming segment will be introduced by Dennis Quaid and will provide some of the best options for treating migraine symptoms.

Viewpoint is an award-winning educational short television program. The show is created by a team of developers and content providers.

Media contact

Development department, point of view with host Dennis Quaid, 561-244-7620, [email protected]

QUELLE viewpoint with host Dennis Quaid

Dock House Nutrition opens in Quincy

Kelli and Tim Martin, co-owners of Dock House Nutrition in Quincy, with their daughter Ava.

Dock House Diet

place: 878 E. Chicago Road, Quincy, (517) 639-2424.

Open: June 15, 2021.

Co-owner: Tim and Kelli Martin.


  • Monday-Friday, 6 a.m.-4 p.m.
  • Saturday, 7 a.m. – 2 p.m.

Do you already have experience in corporate management?

We own K&T Construction from Hillsdale.

What are the unique selling points of your company?

We are not a company, we are a lifestyle. We specialize in the health of our community. We are proud of our smile.

Describe your services and products:

We offer meal replacements, smoothies, tea and energy bombs.

What has inspired your company?

Tim: The results that I had. In the past year, I’ve lost 50 pounds and actually stopped all of my diabetes medication.

On June 15, Dock House Nutrition in Quincy was severed and officially opened.

Take painkillers after vaccination? Dr. Mallika Marshall Answers Your COVID Questions – CBS Boston

  Take painkillers after vaccination?  Dr.  Mallika Marshall Answers Your COVID Questions - CBS Boston

BOSTON (CBS) – Dr. Mallika Marshall answers your medical questions about the coronavirus vaccine. If you have a question, send her an email or send her a message on Facebook or Twitter.

Dr. Mallika gives her best advice, but as always, consult your personal health care professional before making any decisions about your personal health.

Cindy writes: “I was wondering if my husband and I still have to spray mail and parcels that come into the house when we are fully vaccinated? Do we have to wash our hands after handling the mail and parcels? “

If you are fully vaccinated and not immunocompromised, you have very little risk of actually developing COVID-19. So you don’t have to keep wiping packages or groceries like we all did at the start of the pandemic. However, you should continue to wash your hands regularly to reduce the chance of other respiratory viruses, such as those that can cause a cold.

Don writes on Facebook: “I have a history of blood clots in my feet and legs. Would it be safe to get COVID vaccinations? “

In general, you can and should get vaccinated against COVID-19, even if you have had blood clots in the past. Here in the US, the Johnson and Johnson vaccine is the only one that has been linked to a very rare form of blood clot, but the Moderna or Pfizer vaccines are not. Also, COVID-19 can cause blood clots on its own, which can be fatal, so please get vaccinated.

Another question from Facebook. Paul writes: “My wife and I just got the J&J vaccine. I have no pain from the injection, but I have sciatica. Is it okay to take Advil or Tylenol now? “

Sorry for the late reply. Yes, if you have pain after vaccination, you can take over-the-counter pain relievers. Hope you feel better

Patricia von Peabody writes: “Our 50 year old son and our 12 year old grandson are planning to visit us in July from California. You are not vaccinated and you are not going to be vaccinated. All other members of our immediate family are fully vaccinated. Is there a risk of COVID infection if we stay in a single apartment?

It is very unlikely that someone who has been fully vaccinated is at significant risk of infection unless you are immunocompromised and therefore may not have developed a good immune response to the vaccine. However, the unvaccinated family members are still at risk and should continue to wear masks and social distancing, especially when in the presence of other unvaccinated individuals.

Prescriptions, chiropractic and a return to the integrative family doctor?


When it comes to the family doctors and non-drug care vs. prescriptions, ‘I’ll take my half down the middle …The Lagom Way!’

No one could have ever imagined what happened in 2020. The societal middle ground disappeared. You were either for us or against us. “Cancel culture” created a vacuum in the middle of society. Common sense, free speech, and unbiased scientific research all but disappeared. If you apply this societal vacuum to the chiropractic pharmaceutical prescription debate, on one end is the ability of a chiropractor to prescribe medications freely like the medical family doctor, and on the other end is never taking or recommending any pharmaceutical medication, even if it is potentially lifesaving.

3 ways to look at a story

The 2020 rip in our social fabric pushed our profession to the brink of making the same fatal mistake the cancel culture did. Most of us falsely believe we have only two choices. Do we become another health care provider prescribing medication for symptoms or do we stand for what our predecessors believed and address the underlying cause of those symptoms?

In my opinion, chiropractic’s drugless, non-surgical approach to health is the hill I am willing to die on. But that still doesn’t mean I only have two choices in this debate. This turmoil reminds me what an incredibly wise man shared with me long ago. He said, “There are three ways to look at every story. Your way, my way, and what really happened somewhere in the middle.”

I believe chiropractic could own the middle ground of what is really happening in U.S. health care right now. The Gallup poll in December of last year stated that six out of 10 Americans believe we have a major crisis or problem with our current health care system. Our profession has a once-in-a-lifetime opportunity to become an entirely new type of health care provider.  What if chiropractic became the new “Integrative Healthy Lifestyle Primary Care Provider” in the middle of these two extremes?

Integrative care

Many chiropractors (including myself) already provide this type of care to our patients. We live in the middle of the road. Scandinavians call it the “Lagom Way.” Loosely translated, it means “Just enough, but not too much.” This mindset was used to navigate the COVID-19 pandemic in Sweden. I believe there is a time for lifesaving medication, but my training and philosophy does not compel me to be the one prescribing it.

I’ve been a member of my local volunteer fire department for over 23 years. When I arrive on the scene of a terrible accident, the ambulance isn’t taking those victims to my office, it’s going to the emergency room for lifesaving interventions. We have the best medical model in the world for trauma and acute disease management. If I get in an accident, I will happily take my ambulance ride for acute lifesaving medical care.

However, the U.S. health care system has the highest chronic disease burden of all 11 countries that take part in the Commonwealth Fund’s International Health Policy Survey. More than 25% of U.S. adults report two or more chronic conditions. This rate is twice as high as in the Netherlands and the UK.[1]

Different approaches and opportunities

Just as the average medical family doctor has not been formally trained in nutrition, fitness, functional and lifestyle-based interventions, I have not been formally trained in pharmaceutical medicine. Medical professionals have dedicated their lives to the pursuit of allopathic knowledge. I have not. It doesn’t make either of us bad people; it just makes us different in the way we approach our patients.

Medical training is based on Germ Theory. Chiropractic training is more Terrain Theory based. Neither completely explains any specific patient encounter. Some isolated situations require acute medical intervention. However, most ongoing patient encounters do not. Our chiropractic training and philosophy is the logical choice for providing the holistic lifestyle-based approach needed to successfully address chronic patients in our current failing health care system.

Chiropractic’s opportunity is fueled by the lack of access to lifestyle-based primary care in the U.S. We know from Commonwealth Fund surveys that U.S. adults experience great affordability barriers to access lifestyle-based primary care. This leads to only acute and infectious disease visits. Increasing access to affordable health care and strengthening lifestyle-based care are two of the most important challenges for the U.S. health care system.[2]

pharmaceutical prescription crisis

I’m fully aware some chiropractors would love the acceptance of our current medical health care model. Most older adults (especially 65 and over) continue to embrace the U.S. pharmaceutical industry. In 2017, Consumer Reports surveyed 1,947 adults and more than half of them took an average of four prescription drugs regularly.

According to Quintiles IMS in 2017, the number of prescriptions filled by all Americans increased by 85% in the last two decades while the U.S. population only grew by 21%.

Other chiropractors point to pharmaceutical failures, like the opioid crisis, to make their case against prescribing or even recommending medications. Adverse drug events cause approximately 1.3 million emergency department visits and 124,000 deaths each year, according to the CDC and FDA. No medical professional I know is comfortable with those statistics.

ddressing the root problem

My view is those two extremes need to be recognized, but then personal experience, common sense, education and gut feeling should guide your decision for the patient standing in front of you. Pharmaceuticals are not inherently bad; there is certainly a time and place for them. But my focus is to find and correct the root cause of my patient’s problem.

This brings me back to the Lagom Way, “Just enough, but not too much.” Chiropractors are in the perfect position, like the old family doctor, to talk nutrition, fitness, stress reduction, sleep and social interactions, while providing life-changing chiropractic care. We put our hands on people. We touch and connect with them. No other profession combines healthy lifestyle education and personal connection the way chiropractic does.

Taking advantage of a societal disruption

The societal disruption in 2020 could be the best thing to ever happen to chiropractic. Society already views us as different than other health care providers. Most people still have no idea what we do.

Our poor levels of insurance reimbursement have made our fees reasonable for almost everyone. We also have a much lower barrier of entry than other medical providers. These factors, along with our innate ability to connect with our patients, pave the way to create an entirely new integrative healthy lifestyle-based primary care system affordable to all.

Health care and “Big Pharma” spending on direct-to-consumer marketing grew almost 4% in 2020 to $35.7 billion. There is no way chiropractic can compete at this level. However, no amount of marketing dollars will ever top your patient telling their neighbor about the great experience they just had in your office.

They will tell others how you talked to them like an adult, not a child. You explained diet, fitness, stress management and how those things relate to their symptoms. You told them you are willing to be their partner in health. You discussed their medications but referred them to their medical doctor for any specific questions or concerns. In other words you became their trusted authority in creating and maintaining a healthy lifestyle, not focusing on sickness.

Re-emergence of the old-time family doctor

I’m reminded of the old-time family doctor before medications became widely available. They lived next door. They were part of the community. Their practice was based on educating people about a healthy lifestyle. They asked about diet. They asked how you slept last night. They talked about exercise and your family relationships. The family doctor cared about all of you, not just your labs and medication list.

Chiropractors have the opportunity to become the reincarnation of the old-time family doctor. Last year was a huge wake-up call for all of us. The vacuum has cleared the path for chiropractic to stand in the middle of the road and stake our claim as the integrative healthy lifestyle doctor of the future. Many of us have been doing this for years already. Now, it’s time to seize the day.

Who’s with me?

BILL HEMMER, DC, has been in private practice for more than 30 years. He has expanded his practice to include customized health recovery plans and can be reached at [email protected]


[1] Roosa Tikkanen and Melinda K. Abrams, U.S. Health Care from a Global Perspective, 2019: Higher Spending, Worse Outcomes? (Commonwealth Fund, Jan. 2020). https://doi.org/10.26099/7avy-fc29

[2] Eric C. Schneider and David Squires, “From Last to First — Could the U.S. Health Care System Become the Best in the World?,” New England Journal of Medicine 377, no. 10 (Sept. 7, 2017): 901–3; and Eric C. Schneider et al., Mirror, Mirror 2017: International Comparison Reflects Flaws and Opportunities for Better U.S. Health Care (Commonwealth Fund, July 2017).

The post Prescriptions, chiropractic and a return to the integrative family doctor? appeared first on Chiropractic Economics.

By: Bill Hemmer
Title: Prescriptions, chiropractic and a return to the integrative family doctor?
Sourced From: www.chiroeco.com/family-doctor/
Published Date: Tue, 15 Jun 2021 18:48:43 +0000

Save $ 21 on Amazon’s Best Selling Pillow, Today Only

Save $ 21 on Amazon's Best Selling Pillow, Today Only

Yahoo Life is committed to finding you the best products at the best prices. Although this content is independently authored by our editors, we may receive a percentage of purchases made through links on this page or other compensation. Prices and availability are subject to change.

You can get a twin pillow for just $ 35! (Photo: Amazon)

Quick question: when was the last time you got a new pillow? If it’s been a while then, you need an upgrade – and there’s no better time to act than today.

Amazon has cut the price of its best-selling Viewstar pillows by up to 37 percent. For today only, you can purchase a two-pack of fluffy king-size pillows for just $ 34 (up from $ 55).

Thanks to their down-like microfiber filling, the Viewstar pillows have just the right medium-soft feel. A gusseted side band helps the pillow hold its shape so you don’t have to worry about it collapsing on you. The whole thing is wrapped in a microfiber cover for a cuddly soft wearing comfort.

The set of two pillows, available in standard size ($ 31 with coupon), queen size ($ 26, $ 39), and king size ($ 34, $ 55), comes with one excellent head and neck support to make you feel comfortable while sleeping. The pillows are also versatile enough for side, stomach and back sleepers.

You can even choose from the color of your moldings: white, golden brown, dark blue, and blue. Note, however, that prices vary slightly depending on the equipment you choose.

You need this on your bed.  (Photo: Amazon)

You need this on your bed. (Photo: Amazon)

Shopping: Viewstar King Pillow, $ 34 (was $ 55), amazon.com

The pillows are made from a down alternative and certified by OEKO-TEX, which guarantees their safety and quality. And that’s a nice extra: the pillows are machine washable and keep their shape even after washing!

These pillows have an army of fans including some who say they helped with their chronic pain. “These pillows are the best my husband and I have ever owned,” one fan wrote on the reviews. “We no longer have neck or shoulder pain and they have kept their softness and support wonderfully.”

The story goes on

Another happy customer said he bought the pillows specifically because he was struggling with neck pain. “One night on this one and I could tell a difference right away,” they said. “My neck pain has improved dramatically.”

A self-proclaimed “pillow snob” said she “absolutely LOVVVVEEEEE” the pillows. “These pillows were the best I’ve bought from farrrrrrr over the years! They are so soft and fluffy, but still firm and firm!” Another fan said they “love these so much”, adding that they are “incredibly comfortable, not too tall and stiff to cause neck problems, and not too soft to have no support”.

Again, these pillows are only available for today. Do not miss this great offer!

Shop it: Viewstar King Size Pillow, $ 34 (was $ 55), amazon.com

The reviews quoted above are the most current versions at the time of publication.

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Darren Yaw Foods is entering the lucrative sports nutrition beverage market in Southeast Asia with the launch of Yawzer

Darren Yaw Foods is entering the lucrative sports nutrition beverage market in Southeast Asia with the launch of Yawzer

EQS News / 6/16/2021 / 10:00 PM EST / EDT

Darren Yaw Foods is entering the lucrative sports nutrition beverage market in Southeast Asia with the launch of Yawzer


Company update

JAKARTA, INDONESIA / ACCESSWIRE / June 17, 2021 / Food and nutrition brand Darren Yaw Foods announced today that it has entered the growing sports nutrition beverage market with the upcoming Yawzer range of energy drinks.

‘We are excited to announce our launch of the Yawzer line of sports nutrition drinks. Yawzer is a pure and natural sports drink for all ages. It consists of 100% plant-based ingredients, natural caffeine, vitamin C and electrolytes and is suitable for the health conscious young consumer, ”said Lester Yaw Foo Hoe, CEO of Darren Yaw Foods, from the Malaysian office.

As an Asian food company, Darren Yaw Food’s Yawzer beverages are fortified with Asian ingredients that provide additional nutritional benefits such as goji berries, ginseng and ginger. Darren Yaw Foods embarked on a yearlong research and development process that examined the market and beverage segment.

“We know from our market research that Asian consumers are becoming more and more health conscious. This will drive growth in nutritious food and ready-to-drink products in the region. Since sports drinks are increasingly viewed as soft drinks, sports nutrition drinks are now part of the mainstream market. We definitely see huge potential at Yawzer because we are natural and organic and have an extra Asian touch that is definitely unique and a USP, ”said Lester Yaw Foo Hoe, CEO of Darren Yaw Foods.

The global sports nutrition food and drink market is forecast to reach $ 25 billion by 2026, while the Asia-Pacific region is projected to reach $ 9 billion. Asia’s young consumers are a fitness crazy generation, and the health image of sports drinks is driving growth in the sports and energy drink segments. These drinks often contain large doses of caffeine and other legal stimulants.

Yawzer by Darren Yaw Food, on the other hand, uses organic green tea and natural, low-sugar and Asian ingredients and was developed as part of a balanced, healthy diet. ‘We designed Yawzer to fit the modern healthy lifestyle that is trending among young consumers. These consumers are careful about what they eat and drink. Our high quality ingredients with an Asian touch meet these tastes, ”said Lester Yaw Foo Hoe, CEO of Darren Yaw Foods.

In addition, Yawzer plans to integrate sustainable packaging as a marker for the company’s sustainability goals set in 2016. The manufacturer plans to make the range of beverages climate-neutral. ‘Darren Yaw Foods is serious about managing and reducing our carbon footprint. Our manufacturing processes from end-to-end to filling and packaging will be sustainable. Yawzer’s packaging is 100% recyclable and made from low-carbon materials. Our consumers are also interested in the effects of their diet and lifestyle, so we want them to know that Yawzer is the right choice, ”said Lester Yaw Foo Hoe, CEO of Darren Yaw Foods.

Darren Yaw Foods plans to launch Yawzer in Indonesia in July, followed by additional markets in Malaysia, Cambodia, Singapore and Vietnam between 2021 and 2022. The company has signed distribution agreements with local Indonesian convenience retailer GCG, the Guardian Capital Convenience Group belongs.

Darren Yaw Foods’ move signals a move to grow and nurture a fan base of conscious consumers among Gen Zs who are and are looking for ethical, plant-based, and vegan options more willing than ever to spend on sustainable products. The company believes there is a good market among the growing Southeast Asian middle-class youth. The cards for the company represent further expansion in nutrient-rich foods with ready-to-drink products as well as energy bars and protein drinks.

“We are ready to push full steam ahead into this sector and plan to steadily introduce products with all-natural ingredients that offer long-lasting and sustainable energy benefits, taking into account the ever-changing taste trends that the youth market craves.” said Lester Yaw Foo Hoe, CEO of Darren Yaw Foods.

Company information

Darren Yaw Foods is a food manufacturer and retailer based in Indonesia.

For more informations:

visit experience
Jakarta, Indonesia
E-mail: [email protected]

SOURCE: Darren Yaw Foods

June 16, 2021 Publication of a marketing press release, transmitted by the EQS Group.
The issuer is solely responsible for the content of this announcement.

Media archive on www.todayir.com

Sports health professionals say that restricting activity too much after a concussion can actually make symptoms worse

Sports health professionals say that restricting activity too much after a concussion can actually make symptoms worse

Too much rest after a concussion can actually delay an athlete’s recovery and prolong symptoms, a US panel of experts recommended in an updated concussion consensus statement.

“Most athletes who have had a concussion get better and can play again,” said Dr. Margot Putukian, a member of the panel of experts that drafted the consensus statement.

Putukian and her peers say that the number of first symptoms an athlete experiences and their severity are the best determinants of how long recovery will take. However, most adult athletes recover fully within two weeks, and children within four weeks.

Symptoms of a concussion include amnesia, disorientation, brain fog, slurred speech, headache, dizziness, hypersensitivity to noise, and impaired vision.

“Each injury is unique and has its own schedule. But athletes should rest assured that there are treatments in place and steps they can take to aid their own recovery, ”Putukian said in a statement.

While sports-related concussions remain a concern in the US, the highest rates are observed in men in collision sports such as soccer, wrestling, ice hockey, and lacrosse. Concussion rates are also high in girls’ and women’s football.

Risk factors for a more complicated recovery, according to the updated statement, include younger age, previous concussions, loss of consciousness for more than a minute, and pre-existing conditions such as migraines, attention deficit hyperactivity disorder, learning disorders, mood disorders, and motion sickness.

Gradually returning to moderate aerobic exercise in the first week after a concussion will help speed recovery, the experts said.

Any lingering symptoms, such as fatigue, headache, and anxiety, are usually the result of a “complex interaction” of several factors, including previous illnesses and the physical and mental effects of the concussion.

Treatment for concussions should focus on specific symptoms, the statement said, and may include cognitive behavioral therapy, as well as improved sleep, diet, and hydration. Most injured athletes do not need over-the-counter or prescription drugs to manage their symptoms.

Putukian and her co-panelists also looked at the available data on nutraceuticals. Foods and supplements that offer health benefits and found that they did not help prevent or treat a concussion.

They also noted in the updated statement that diagnosis is one of the hardest parts of treating a concussion. There are currently no specific blood or imaging tests that can detect a concussion, and many of the symptoms can be related to various health conditions.

Because of this, the true incidence of exercise-related concussions is still unknown.

Panellists also recommend that coaches and relatives of concussion athletes watch out for symptoms that may indicate a more serious brain or neck injury that requires immediate emergency care – seizures, loss of consciousness lasting more than a minute, persistent vomiting, increasing confusion , Tingling or numbness in the extremities, and neck pain.

The consensus statement, which is an update of a 2011 published, was published in the British Journal of Sports Medicine. Panelists included experts from six major professional associations, including the American Academy of Orthopedic Surgeons and the American College of Sports Medicine.

Cognitive Function and WMLs in Medication-Overuse Headache

Cognitive Function and WMLs in Medication-Overuse Headache


Medication-overuse headache (MOH) is defined as a chronic headache that occurs on 15 or more days per month for more than 3 months in patients with a pre-existing primary headache caused by overuse of symptomatic headache medications, and the overall prevalence of MOH in the general population is about 1–2%.1 According to the Global Burden of Disease Study 2015, MOH is the 20th cause of disability worldwide, which causes an impairment in the quality of life for sufferers and causes a heavy financial burden on society.2

As a type of common chronic headache which developed from primary headache, MOH possessed longer disease duration and more attack frequencies. Neuroimaging studies indicated an increased prevalence of brain white matter lesions (WMLs) in migraine patients,3,4 and disease duration and headache attack frequency were indicators of WMLs in migraine.5,6 Moreover, our previous study suggested that WMLs were more prevalent in MOH patients.7

Cross-sectional studies showed that cognitive impairment was frequent in patients with chronic migraine and patients with chronic tension-type headache,8–10 and migraine and tension-type headache were also associated with non-vascular dementia.11 Our recent study found that the risk of cognitive decline was elevated in MOH patients.12

WMLs were associated with impaired cognitive function,13 and the severity of WMLs at baseline was associated with the cognitive decline in the non-demented elderly over time.14 However, the relationship between cognitive function and WMLs in MOH patients was not yet clear. This study was performed to investigate the cognitive function and WMLs and the relationship between them in MOH patients.



This cross-sectional study was conducted between June 2016 and October 2019. The participants were recruited from the MOH patients attending the Department of Neurology, Fujian Medical University Union Hospital. Only patients who met all the following criteria were enrolled in the study: (a) diagnosis of MOH based on the third edition of the International Classification of Headache Disorders (beta version);15 (b) headache duration ≥ 1 year; (c) without preventive treatment or detoxification before; (d) age between 18–80; (e) absence of dementia, including Alzheimer’s disease, vascular dementia, and frontal temporal dementia, severe mental illness, neoplastic diseases, infectious diseases, rheumatic diseases or connective tissue diseases. Healthy subjects without a personal or family history of primary headache visiting our hospital for medical checkups during the study period were served as a healthy control group. All procedures performed in studies involving human participants were in accordance with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This study was approved by the Ethics Committee of Fujian Medical University Union Hospital and informed consent was obtained from all individual participants included in the study.

Baseline Information Collection

The age, sex, years of schooling, accompanied hypertension, diabetes, smoking history, underlying primary headache, disease duration, and monthly headache days of the participants were investigated. Smoking history was defined as smoking at least 3 cigarettes per day on average for more than one year.

Neuropsychology Assessment

General cognitive function, anxiety, depression, and sleep quality were assessed with Montreal Cognitive Assessment (MoCA, Chinese-Beijing Version) (www.mocatest.org), Hamilton Anxiety Rating Scale (HAMA),16 Hamilton Depression Rating Scale (HAMD-24),17 and Pittsburgh Sleep Quality Index (PSQI),18 respectively by two trained physicians (Shenggen Chen and Hanbin Lin) blind to the clinical data. MoCA scores more than 25 (of 30), HAMA scores less than 7 (of 56), HAMD-24 scores less than 8 (of 76), and PSQI scores less than 7 (of 21) were classified as normal. According to the MoCA scores, the recruited MOH patients were divided into two groups, ie, patients with MoCA scores of more than 25 were classified into MOH with normal cognition group, and patients with MoCA scores of less than 26 were classified into MOH with cognitive impairment group.

MRI Evaluation

A 3.0-tesla MRI scanner (Prisma, Siemens Medical Systems, Erlangen, Germany) was employed to acquire images. The MRI protocol consisted of axial T1-weighted images (TR/TE, 2500 ms/10 ms), axial T2-weighted images (TR/TE, 4500 ms/80 ms), and coronal FLAIR images (TR/TE, 8000 ms/100 ms). For each image series, 35 slices covering the entire brain (matrix 224 × 224; FOV 224 mm × 224 mm; slice thickness 4.0 mm without gap) were obtained.

WMLs were defined as hyperintense focal lesions on T2-weighted and FLAIR images and iso- or hypo-intense on T1-weighted images. WMLs were scored with Fazekas scale by two trained raters (Yue Xiang and Wenting Xiong) blind to the clinical data on a consensus basis. Fazekas scale scores were developed as a sum of periventricular white matter hyperintensity scores and deep white matter hyperintensity scores. Periventricular white matter hyperintensity was graded as 0 = absence, 1 = “caps” or pencil-thin lining, 2 = smooth “halo”, 3 = irregular periventricular hyperintensity extending into the deep white matter. Deep white matter hyperintensity was graded as 0 = absence, 1 = punctate foci, 2 = beginning confluence of foci, 3 = large confluent areas.19

Statistical Analysis

Normality tests were performed to reveal the distribution of age, years of schooling, disease duration, monthly headache days, MoCA scores, HAMA scores, HAMD-24 scores, PSQI scores, and Fazekas scale scores before statistical analysis. For normally distributed data, they were expressed as the mean and standard deviation (SD), and the differences between groups were tested with independent samples t-test. For non-normally distributed data, they were expressed as the median and inter-quartile range (IQR), and the differences between groups were tested with Mann–Whitney U-test. Differences in sex, accompanied hypertension, diabetes, and smoking history were tested with chi-square test. Correlations between MoCA scores and age, years of schooling, disease duration, monthly headache days, HAMA scores, HAMD-24 scores, PSQI scores, and Fazekas scale scores were analyzed using Spearman correlation analysis. Binary logistic regression models were used to estimate the risk factors for cognitive impairment in MOH patients. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. A two-tailed P-value < 0.05 was considered statistically significant. All statistical analyses were performed using IBM SPSS Version 26.0 for Windows (SPSS Inc., Chicago, IL, USA).


Baseline Information

Forty-six healthy controls (27 women, 19 men) and eighty-eight MOH patients (49 women, 39 men) who met the inclusion criteria were enrolled into this study, 40 of the MOH patients for MOH with cognitive impairment group and 48 for MOH with normal cognition group. The drugs overused by MOH patients in our study included acetaminophen, ibuprofen, aminopyrine, phenacetin, diclofenac, loxoprofen, propyphenazone, aspirin, and combinations of simple analgesics. The age, sex, years of schooling, the incidence of hypertension, the incidence of diabetes, and the incidence of smoking history between healthy controls and MOH patients showed no significant difference (Table 1). The sex, years of schooling, the incidence of hypertension, the incidence of diabetes, the incidence of smoking history, and the incidence of migraine as primary headache between MOH patients with cognitive impairment and MOH patients with normal cognition showed no significant difference. However, the age, disease duration, and monthly headache days in MOH patients with cognitive impairment were greater than those in MOH patients with normal cognition (Table 2).

Table 1 Demographic Characteristic of Study Participants

Table 2 Demographic Characteristic of MOH Patients

Neuropsychology Assessment

MOH patients had significantly lower MoCA scores compared to healthy controls, including the scores of visuospatial and executive function, attention, and orientation, while HAMA scores, HAMD-24 scores, and PSQI scores in MOH patients were greater than those in healthy controls (Table 3). The HAMA scores, HAMD-24 scores, and PSQI scores between MOH patients with cognitive impairment and MOH patients with normal cognition showed no significant difference (Table 4).

Table 3 Neuropsychology Assessment in Study Participants

Table 4 Neuropsychology Assessment in MOH Patients

WML Evaluation

Fazekas scale showed that MOH patients had significantly greater deep white matter hyperintensity scores compared to healthy controls, while periventricular white matter hyperintensity scores between them showed no significant difference (Table 5). Periventricular white matter hyperintensity scores in MOH patients with cognitive impairment were greater than that in MOH patients with normal cognition, while deep white matter hyperintensity scores between them showed no significant difference (Table 6).

Table 5 WMLs in Study Participants

Table 6 WMLs in MOH Patients

Correlations Between MoCA Scores and Baseline Information, HAMA Scores, HAMD-24 Scores, PSQI Scores, and Fazekas Scale Scores in MOH Patients

In MOH patients, MoCA scores were negatively related to age (r = −0.315, P = 0.003), disease duration (r = −0.584, P < 0.001), monthly headache days (r = −0.494, P < 0.001), and Fazekas scale scores (r = −0.463, P < 0.001; Table 7).

Table 7 Correlations Between MoCA Scores and Baseline Information, HAMA Scores, HAMD-24 Scores, PSQI Scores, and Fazekas Scale Scores in MOH Patients

Risk Factors for Cognitive Impairment in MOH Patients

Univariate logistic regression analysis revealed that age, disease duration, monthly headache days, and Fazekas scale scores were the independent risk factors for cognitive impairment in MOH patients (P < 0.05), while years of schooling, HAMA scores, HAMD-24 scores, PSQI scores, sex, accompanied hypertension, diabetes, smoking history, and underlying primary headache were not the independent risk factors (P > 0.05; Table 8). Therefore, four covariates, including age, disease duration, monthly headache days, and Fazekas scale scores, were included in our final multivariate logistic regression model to estimate the potential risk factors for cognitive impairment in MOH patients. Disease duration and monthly headache days were found to be significant predictors of cognitive impairment in MOH patients (OR, 1.31; 95% CI, 1.11–1.55; P = 0.002 and OR, 1.42; 95% CI, 1.20–1.68; P < 0.001 respectively; Table 9).

Table 8 Risk Factors for Cognitive Impairment in MOH Patients (Univariate Logistic Regression Analysis)

Table 9 Risk Factors for Cognitive Impairment in MOH Patients (Multivariate Logistic Regression Model)


Our study indicated that MOH patients had significantly lower MoCA scores, especially in the domains of visuospatial and executive function, attention, and orientation, while they had significantly greater HAMA scores, HAMD-24 scores, PSQI scores, and deep white matter hyperintensity scores compared to healthy controls. And in MOH patients, the age, disease duration, monthly headache days, and periventricular white matter hyperintensity scores in patients with cognitive impairment were greater than those in patients with normal cognition. Moreover, the MoCA scores were negatively related to age, disease duration, monthly headache days, and Fazekas scale scores, and disease duration and monthly headache days were significant predictors of cognitive impairment in MOH patients.

MOH patients demonstrated impaired general cognition as indicated by lowered MoCA scores, particularly in the domains of visuospatial and executive function, attention, and orientation. Altered volume in cerebellum and regions related to affection and cognitive processing (right lateral orbital gyrus), visual (left calcarine, bilateral middle occipital gyrus, right superior parietal lobe, optic chiasm), and auditory (right temporal transverse gyrus) perception was observed in MOH patients,20 which could be a morphological basis of cognitive impairment in MOH. Besides, MOH patients possessed prolonged P3 latency and lowered P3 amplitude, which could provide electrophysiological evidence for cognitive impairment in MOH.21

MOH was considered to be associated with psychiatric comorbidities such as depression, anxiety, and insomnia,22 and these comorbidities could be risk factors in the evolution of migraine into MOH.23,24 Increasing headache frequency was associated with risk of occurrence of anxiety, depression, and insomnia,25 and higher migraine frequency was correlated with greater symptom scores of anxiety and depression.26 MOH patients showed a high rate of depression and anxiety, which could negatively affect their headache attack,27 and depression and anxiety were found to be negative predictors in terms of treatment response in chronic migraine patients with or without medication-overuse.28–30 Moreover, lowered depression scores predicted a positive outcome of MOH detoxification.31 Furthermore, the volume of lower hippocampal subfields was negatively related to anxiety conditions in MOH patients.32

Recent studies suggested an increased prevalence of WMLs in migraine patients, especially deep WMLs,33 and our previous study showed that MOH patients had a greater prevalence of high WML load and they were at elevated risk of high deep WMLs load compared to healthy controls,7 which was in line with our finding that MOH patients possessed greater deep white matter hyperintensity scores compared to healthy controls.

We found that MoCA scores were negatively related to Fazekas scale scores in MOH patients, and periventricular white matter hyperintensity scores in patients with cognitive impairment were greater than that in patients with normal cognition. WMLs were implicated in the progression of cognitive impairment, and WMLs located at different regions, including periventricular and deep WMLs, evolved differently. A systematic review suggested that periventricular WMLs could have a significant negative impact on the cognition of older adults.34 To be more precise, frontal WMLs in the proximity of the frontal ventricles mainly affected executive function and parieto-temporal WMLs in the proximity of the posterior horns deteriorated memory.35 Moreover, the frontal component of periventricular WMLs was associated with pronounced cortical atrophy, and the dorsal component of periventricular WMLs showed associations with the cognitive decline.36 Additionally, periventricular WMLs were involved in the rate of cognitive decline.37 The underlying mechanisms of cognitive impairment caused by periventricular WMLs included impairment of nodal path length in the left opercular part of the inferior frontal gyrus,38 decreased regional cortical grey matter blood flow,39 disproportionate progressive hippocampal atrophy,40 and cortical atrophy.41

Age was associated with cognitive impairment among MOH patients. Age-related cognitive changes, including neuronal structure alterations, synapse loss, and neuronal network dysfunction result in brain structural and functional changes, and age-related diseases accelerate neuronal dysfunction, neuronal loss, and cognitive decline.42

Migraine has been linked to an increased prevalence of cognitive impairment, and the duration and frequency of migraine affect cognitive function.43 WMLs are more prevalent in migraine patients, and the disease duration and attack frequency have key roles in the formation of WMLs.6 WMLs may media the development of cognitive impairment in migraine. MOH patients had a high prevalence of cognitive impairment and WML burden,7 and the cognitive function was negatively related to WML burden. Our study indicated that the disease duration and headache frequency were the potential predictors of cognitive impairment in MOH patients. It could be assumed that longer disease duration and higher headache frequency in MOH could cause more serious WMLs, which would consequently lead to cognitive impairment. Further studies are needed to elucidate the mechanisms of the prevalence of cognitive impairment and WMLs in MOH.

Several limitations in this study should be considered when interpreting the findings. Firstly, the cross-sectional survey of this study indicates associations between cognitive impairment and some risk factors. However, this study cannot determine whether these associations are causal. Additional longitudinal cohort studies will be needed to carry out the evaluations. Secondly, due to the strict inclusion criteria, a relatively small number of participants were enrolled into this study. Additional studies with a larger sample size are required to confirm our results.


MOH patients showed cognitive impairment and increased WML burden. And in MOH patients, cognitive function was negatively related to WML burden, and disease duration and monthly headache days were potential predictors of cognitive impairment. Our findings indicate that prompt and effective treatment to stop the progression of the disease may alleviate cognitive impairment in MOH patients.


This work was supported by grants from the Training Project for Young and middle-aged core talents in the Health system of Fujian province (grant No. 2017-ZQN-38), Natural Science Foundation of Fujian province (grant No. 2017J05126), and Sailing Fund Project of Fujian Medical University (grant No. 2016QH022).


The authors report no conflicts of interest in this work.


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Learn which exercises work for maintaining cognitive health

Learn which exercises work for maintaining cognitive health

As previously known, following a weekly exercise routine improves physical health. What many do not know is that cognitive health is also worked with. According to Cleveland Clinic neuropsychologist Aaron Bonner-Jackson, Physical and aerobic exercise are beneficial for maintaining brain health, especially in People at risk of developing dementia and Alzheimer’s disease.

“To maintain cognitive health, it is best to train your body and mind with daily exercise and stimulating social activities,” said the expert. Bonner-Jackson mentioned that physical activity can benefit the brain in a number of ways, including: reducing inflammation, lowering stress hormones, improving blood circulation, and promoting cardiovascular health.

“Exercise can also bring physical benefits to the brain, such as B. Enlarging the cerebral cortex and improving the integrity of the white matter, the nerve fiber, that connects areas of the gray matter of the brain that are rich in nerve cells. It also promotes neuroplasticity, the brain’s ability to form new neural connections, ”adds the specialist.

How to create mental stimulation

The neuropsychologist pointed out that there are many potential exercise mechanisms that can be combined for the benefit of this organ. For example, he stated that it is very beneficial to be physically active for 150 minutes a week, with activities such as walking, jogging, cycling, or swimming.

He also recommended trying new mental stimulation activities, such as reading a book or learning new carpentry and gardening skills. Put together puzzles, solve math problems, or master a new language or musical instrument.

As a final tip, Bonner-Jackson said it was beneficial to schedule regular meetings with family or friends, join a social organization, or volunteer at a church, hospital, or charity group.

Resonance was created to bring together a community of digital nomads, entrepreneurs, innovators, wisdom keepers, alternative thinkers, mentors and light leaders from around the world to bridge the gap between demanding work and a lifestyle that offers the opportunity to live and to live live in an environment that is nourishing and supportive.

Injured in a car accident? What’s the best treatment?

  Injured in a car accident?  What's the best treatment?

Today I spoke to my physiotherapist who treated me for a shoulder injury (infraspinatus muscle) and we talked about other alternatives to physiotherapy such as chiropractic or acupuncture. He told me that he thought these and other medical methods would be just as effective in some cases and the conversation turned to today’s topic, what would he recommend?

He replied that a very important consideration was the patient’s belief. If the patient believes that the particular treatment regimen is good for them, the likelihood that it actually does is much higher.

Victims of car and truck accidents often ask us what treatment we would recommend. Without exception, our answer is what works best for you.

It may seem like we’re eluding the question, but the fact is that different modalities work for different people, and previous experiences are often telling as to what will work in the future. For patients who have previously successfully recovered from an injury, repetition of this form of treatment often works quite well because the person believes in the effectiveness of the treatment.

This means that patients who found chiropractic, physical therapy, or acupuncture useful for previous injuries often do better if they make better use of this area of ​​treatment for subsequent injuries.

Obviously, some injuries are different from others, and someone who has previously benefited from physical therapy for lower back injuries, for example, may not find it helpful with a concussion. Obviously, injury diagnoses and medical opinions are very important in the treatment to be taken, as some modalities can make an injury worse rather than better.

Once doctors have weighed which treatment would be useful or harmful, decisions are to be made, and if you believe in the benefit of a particular treatment, go for it. Sometimes our clients have no previous treatment experience and we recommend talking to family members and friends about what might have worked for them.

The other important consideration is the implementation of the treatment plan. If your therapist or chiropractor thinks you need six weeks of treatment three times a week, give the treatment. Sometimes our clients say they are not getting better and certainly such concerns should be directed to the healthcare provider, but many injuries take time to heal.

So when you have treatment options, adopt one that you can enthusiastically perform and the chances are you will get better sooner.